Jens Lykkesfeldt
Institut for Veterinær Sygdomsbiologi/Faggruppen for Biomedicin
Adresse:
Ridebanevej 9
1870Frederiksberg C
Research Interests
Redox imbalance in development and disease
Living cells are constantly exposed to reactive oxygen and nitrogen species which may lead to modifications of the cellular macromolecules, mutations and eventually cell death. Increased oxidative stress - i.e. an imbalance in the cellular redox homeostasis - is observed during e.g. smoking, aging and inflammation and has been associated with several chronic diseases including atherosclerosis and cancer.
In a variety of studies ranging from primary cells, cell culture and animal models to clinical trials, we study the effects of oxidative insults on the redox homeostasis as well as the possible benefit of intervention with bioactive compounds to selected groups of animals or humans. Together with measurements of oxidative damage—an effect of oxidative stress—we investigate the link between oxidative stress and various pathological conditions. Our primary goal is to understand the role and mechanism of altered redox status in disease development and thereby pave the road for better prevention strategies and pharmacotherapy for animals and humans.
Background
Positions
2009 to present 2008 | Professor in experimental pharmacology and toxicology at Department of Disease Biology, Life Science Faculty, University of Copenhagen. Professor in biotechnology at Department of Disease Biology, Life Science Faculty, University of Copenhagen. |
1998 to 2007 | Associate professor in pharmacology at Department of Veterinary Pathobiology, Royal Veterinary and Agricultural University. |
1996 to 1998 | Visiting Scientist at Department of Molecular and Cell Biology, University of California, Berkeley, USA |
| 1993 to 1995 | Post doctoral fellow at Department of Pharmacology, University of Copenhagen. |
1990 to 1992 | Ph.D. student at the Plant Biochemistry Laboratory, Royal Veterinary and Agricultural University. |
Academic degrees
2005 | D.Sc. in Medicine from the University of Copenhagen, Denmark. Title of thesis: Vitamin C as biomarker and treatment of oxidative stress caused by smoking - Methodological and clinical studies. |
1992 | Ph.D. in Biochemistry from the Technical University of Denmark. Title of thesis: The biosynthesis of cyanogenic glucosides and glucosinolates in higher plants. |
1989 | M.Sc. in Organic Chemistry and Chemistry of Natural Products from the Technical University of Denmark. Title of thesis: The synthesis of alfa,beta-unsaturated delta-lactones. |
Publications
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In vivo Pharmacology
Dr. Lykkesfeldt is head of the In Vivo Pharmacology PhD program. Read more on our homepage www.invivofarm.dk